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Unexplained blood loss is very difficult. Yes, it can be that blood cells are being destroyed or are not developing properly - but this usually is ultimately explained by a blood cancer and this is clearly not the case in Janet's mother and probably not in your grandpa either. There can be "pooling" of blood in the spleen, and I can't remember what causes that - which can decrease the amount of circulating blood. As strange as it sounds, sometimes they just can't determine where the blood is going and where it is coming from???
Wish I had a better answer.
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 Gayle
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